There are numerous emerging approaches on the horizon that offer the promise to harness the natural biology of wound healing and promote repair. One example stems from the development of novel optical imaging methods that enable an investigation of cell signaling and the progression of repair using the software developed for multidimensional image analysis and enabling a re-interpretation of molecular changes in the wound bed. Yet another originates in the discovery of bacterial communication, signaling trafficking and perception – both between bacteria and between bacteria and eukaryotes. These emerging technologies will be introduced in this session and their possible applications to wound healing discussed in light of the effects on growth factors, matrix remodeling and infection on the wound bed. A panel of wound repair scientists will discuss the impact of these technologies on wound repair.