Understanding how the wound environment can influence biofilm formation is essential in the development of effective therapeutic agents. Over the years, various therapies have been tried to combat biofilms and reduce their ability to form. The focus of this session is review the basic biochemistry of biofilms, how they can be manipulated in the wound care setting and present the evidence of current therapies, e.g. quorum sensing blockers, debridement, antimicrobials, dressings, lactoferrin, antimicrobial peptides, nitric oxide, etc. In addition, a better understanding of how bacterial virulence is related to biofilm presence will be discussed.